Malignant Peripheral Nerve Sheath Tumor (MPNST) 101...Explained by a Sarcoma Pathologist
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Published 2018-04-26
This video explores the clinical, histologic, and immunophenotypic features of MPNST. Malignant Triton tumor and epithelioid MPNST are also discussed. Over 15 different cases of MPNST are shown in the video. Cases/topics discussed (click time stamp to go to that part of the video):
Intro/clinical settings for MPNST: 0:00
MPNST histologic features: 7:00
Example of palisading in MPNST: 25:00 (see WSI digital slide for this case: )
IHC in MPNST: 36:50
Malignant Triton tumor (MPNST w rhabdomyoblastic differentiation): 42:48
Striated rhabdomyoblast in Triton tumor: 58:25
Epithelioid MPNST: 1:06:18
Additional relevant videos:
- Neurofibroma, NF-1, and low grade MPNST: • Neurofibroma, Neurofibromatosis-1, an...
- Schwannoma (neurilemmoma): • Schwannoma (Neurilemmoma)...Explained...
- Synovial sarcoma: • Synovial Sarcoma 101…Explained by a S...
Additional suggested reading:
- Atypical neurofibromatous neoplasms / "low grade MPNST" in setting of NF-1: www.ncbi.nlm.nih.gov/pubmed/28551330
- Our case report of malignant Triton tumor MPNST arising in free flap: www.ncbi.nlm.nih.gov/pubmed/28387148.
Whole slide digital pathology images from the case:
- bit.ly/TritonFreeFlap1
- bit.ly/TritonFreeFlap2
- bit.ly/TritonFreeFlap3
- S100: bit.ly/TritonFreeFlapS100
Please check out my Soft Tissue Pathology & Dermatopathology survival guide textbooks: bit.ly/2Te2haB
This video is geared towards medical students, pathology or dermatology residents, or practicing pathologists or dermatologists. Of course, this video is for educational purposes only and is not formal medical advice or consultation.
Presented by Jerad M. Gardner, MD. Please subscribe to my channel to be notified of new pathology teaching videos.
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All Comments (21)
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A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).
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The best pathology presentations with great cases and helpul info for fellow colleagues. A big thank you from Germany! Keep it up, you make the pathworld better.
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I'm a 19 year old female from Serbia and i had Triton tumor when i was 11, back then it took doctors all around the world a whole month to figure out what it was. I had surgery, went trough chemo and radiotherapy and it was all very experimental. Over the years i've been trying to get a better understanding of the tumor itself but i rarely found anything since it was pretty rare. Now that i tried to research it again in 2022 i was pleasently surprised that there are actual articles about it and mentions of it in this video, thank you for educating us!
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So well explained and demonstrated! Thank you!!
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great video mister GARDNER,thanks a lot for what are you doing
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Love your voice, your descriptions and reading the slides. Super thanks from Turkey.
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Amazing videos as usual. Many thanks dr Gardner for all your wonderful teaching materials
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Perfect ... Clear explanation... Very helpfull .... can't stop the video until the end.
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what an astonishing video prof. You are out of this world. please keep going and continue sharing your fabulous informations.
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Simplified and beautiful illustration, terrific video
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Thanks so much. Very helpful. The slides are wonderful
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Good discussion, excellent cases.
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thank you very much Prof, very clear explanation.
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Great educational video Jerad. Thank you very much
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The video was really helpful sir... Thankyou for making such great videos and sharing your knowledge with us.
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Alas, if seeing eye pictures from the '90's makes you old, then I am too! Another great video, thanks.
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Thank you so much for this.
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Great video
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Loved the rhabdomyoblast with straitions... Had only imagined.. today saw it . Sir we or me would love to hear and learn rhabdomyosarcoma series ... Thanks in advance.
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A great clarity was made certain to my view by your comment upon the beauty, ordering of structure at the known malagancy of multi form tissue. Two decades on with molecular toolbar approach to disease, I am compelled to think of that counterpart beauty quite simply in the ordered complement of amino at gene...both healty and malfeasance to organ procession in process. Thus...so valuable...concrete and useful to thought...deeper study at these pathology. I simply ...quite thank you for your superb and excellence to express these domains at your expertise. I am at once your student. *McGary
