Dr. Sara Gottfried: How to Optimize Female Hormone Health for Vitality & Longevity | Huberman Lab

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Published 2023-01-30
My guest is Sara Gottfried, M.D., a Harvard-trained, board-certified gynecologist and clinical assistant professor of integrative medicine & nutritional sciences at Thomas Jefferson University. Dr. Gottfried specializes in hormone health, vitality and longevity using precision/personalized approaches. We discuss female hormone health, puberty, perimenopause, and menopause, hormone testing, the microbiome, stress related hormone challenges, their causes, and various treatments. We also discuss fertility, birth control and tools for improving microbiome health, treating PCOS, insulin management, and the best nutrition, supplementation, and exercise programs for women. While the episode focuses mainly on female hormones, males will also benefit from our discussion because it includes actionable tools suggested for managing stress, bolstering the gut microbiome, and immunity—all of which stand to improve overall health, vitality and longevity in males and females.

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Dr. Sara Gottfried
Website: www.saragottfriedmd.com/
Academic Profile: bit.ly/3wI7vBz
Medical Practice: bit.ly/3jcopoE
Twitter: twitter.com/drgottfried
Instagram: www.instagram.com/saragottfriedmd
TikTok: www.tiktok.com/@saragottfriedmd
YouTube youtube.com/drgottfried
Facebook www.facebook.com/DrGottfried
LinkedIn: www.linkedin.com/in/drgottfried
The Critical Link Between Healthy Hormones and Your Relationships: bit.ly/40aKXqx

Articles
Women: Diet, Cardiometabolic Health, and Functional Medicine: bit.ly/3WPsjl0
Continuous glucose monitoring metrics for earlier identification of pre-diabetes: protocol for a systematic review and meta-analysis: bit.ly/3HDX9cc
Brief structured respiration practices enhance mood and reduce physiological arousal: bit.ly/3wEvGRf

Books
The Hormone Cure: amzn.to/3RwnhdV
Women Food and Hormones: amzn.to/3uLAM0y

Other Resources
Genova Diagnostics Metabolomix Test: bit.ly/3HDfPc3
Genova Diagnostics NutrEval: bit.ly/3JlHmQB
SpectraCell Laboratories Micronutrient Test: bit.ly/3WMJmnS
Omega Quant Tests: bit.ly/3kUiiFT
Cleveland HeartLab® Cardiometabolic Disease: bit.ly/3Jl4jTX
Genova Diagnostics Stool Test: bit.ly/3JqaVR8
Thorne Gut Health Test: thor.ne/y9GEp
"Men are not the patriarchy," Pat McCabe: bit.ly/3HFU3nW

Timestamps
00:00:00 Dr. Sara Gottfried
00:03:51 ROKA, Thesis, LMNT, Momentous
00:07:50 Women, Family History, Heredity & Environment
00:11:00 Puberty, Stress, Menstrual Cycles, Intrauterine Devices (IUDs)
00:17:26 Tool: Sex Hormones, Microbiome, Estrobolome & Disease; Biomarker Testing
00:25:11 Nutritional Testing; Vegetables, Microbiome & Disease
00:31:13 AG1 (Athletic Greens)
00:32:22 Microbiome, Prebiotics & Probiotics, Inflammation
00:36:08 Microbiome Testing, Magnesium, Constipation & Thyroid
00:42:25 Female Colonoscopy; Network Effect & Modern Medicine, Stress Factors
00:45:13 Constipation, Stress & Trauma, Autonomic Balance
00:55:35 Constipation Relief, Stress, Breathwork & Meditation
01:02:58 Systemic & Societal Stress Unique to Females
01:08:19 InsideTracker
01:09:23 Testing & Future Behavior
01:11:55 Polycystic Ovary Syndrome (PCOS) & Cardiometabolic Disease; Stress
01:22:57 PCOS, Insulin, Glucose Monitoring and Management; Data Access
01:29:48 Behaviors for Vitality; Exercise & Body Phenotype; Cortisol
01:36:40 Cortisol Supplements: Ashwagandha, Rhodiola, Fish Oil, Phosphatidylserine
01:42:36 Cortisol, Anxiety & Immune System; Adrenal Function, Resilience
01:48:07 Tool: Omega-3 Fatty Acids, Inflammation, Specialized Pro-Resolving Mediators
01:54:20 Oral Contraceptives, Benefits & Risks; Ovarian Cancer; Testosterone
02:06:50 Fertility, Follicular & Anti-Mullerian Hormone (AMH) Assessments
02:10:29 Menopause & Hormone Replacement Therapy; Women’s Health Initiative
02:15:30 Perimenopause, Cerebral Hypometabolism, Metabolism & Estrogen
02:21:49 Intermittent Fasting, Ketogenic Diet, Metabolic Flexibility
02:23:29 Stool Testing
02:25:32 Coronary Artery Calcium (CAC) Test, ACE Score & Disease
02:31:56 Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Social Media, Neural Network Newsletter, Momentous

Disclaimer: hubermanlab.com/disclaimer

All Comments (21)
  • @taniasawaya26
    This is THE single best Huberman Lab episode you have ever done, Andrew. On behalf of all women, thank you. Let's hear her again soon, please.
  • Please do a whole episode on Menopause! We as women are given so little information on this and it impacts us sooo much! Our providers gloss over it if we aren’t in the age range of going through it yet but I personally want to be prepared!
  • @marijazil6362
    (Saying louder than everyone else) Andrew, PLEASE bring more people specialising in women's health to your podcast! I love how on many of topics with other guests you make sure to ask 'and what's that like for women?' - it's so important, and so few other big podcasters do. It was refreshing to listen to Sara and not have to quickly google every other claim with added 'for women'. Can't wait to read her books.
  • @amusienk
    I’m so grateful for this episode, Dr. Huberman! I was struggling with infertility and, thanks to the rich content of this episode, was able to self-diagnose PCOS and then confirm it with my doc. I began exercising 30-60 minutes a day, followed by cold showers, and supplementing with high EPA fish oil, L-Carnitine, and Inositol. My sleep improved, joint pain went away, BG went down from 5.7 to 5.6 and within 2 months of this protocol I achieved ovulation. I found out today I am pregnant, on the very first cycle! My husband and I are joyful beyond words!!
  • We definitely need part 2! We didnt get to what women in their 40s and 50+ need to be doing! Also please talk more about women and testosterone replacement!
  • My family think I’m going through some kind of spiritual awakening in my life. I spent two months binge watching this podcast after I hit rock bottom. Andrew hubermans podcast changed my life. He saved my life. Helped with my trauma, grief, depression, anxiety and adhd. I now have a business, in better physical and mental health I’ve not been at in over 10 years! I am so so so grateful to Andrew for this podcast, I hope he knows the impact he has on others. ❤
  • @dmoyeno5172
    I think this is the first podcast that a male host actually cares enough to dive deep with great questions and actively wants to get to solutions on behalf of women. ✨ Thank you. Just amazing bro✨💫
  • @1tecito
    I almost cried in several parts of this podcast because the way you two are adressing this almost INVISIBLE problems women all across the world go through is so rare yet so important.
  • @SageLazuli
    I went to my primary care physician and asked for them to check my hormones including testosterone and he told me I didn’t need to check testosterone because I’m a woman… 🤦🏽‍♀️ Thank you Dr. Huberman for putting so much free information out to the public so we can have the option to educate ourselves. I’ve lost faith in the medical system long ago.
  • @yogini326
    women’s health and wellness topics are largely centred around selling products and services. This is refreshing. Women want to know and understand the science of their bodies. We really need more of this kind of content. Produce more please!
  • @sandra-oc7ye
    I cannot express the relief that menopause research is FINALLY happening. Thank you so much for broadcasting this topic. Please keep women’s health information coming on your podcast. Thank you for your consistent women inclusive dialogue in all your podcasts. ❤
  • @Taliatekito
    This episode is now 7mths old but I’ve recommended it to countless women. The connection between digestion problems and hormone problems is a real AH HA moment. This information is so valuable as anxiety levels are increasing in young females.
  • I was dismayed when 15 min in she made the statement that she's an IUD crusader and said, "Having a copper IUD gives you a complete authority and sovereignty over your sexual life that's profound". When I would argue having complete control over it WITHOUT a foreign substance in it is actual autonomy! Then she goes on to say that "women with the copper IUD have the highest satisfaction rate of anyone on contraceptives". Ironically I just made a post about this on my IG a few days ago, sharing the horrific side effects I suffered from having a copper IUD. All bloodwork showed I was completely "healthy," yet I had suddenly developed numerous unexplainable issues - severe loss of strength, constant phantom pain and injuries, severe memory loss, severe fatigue, and more. My obgyn told me it wasn't possible that it was from my IUD, yet when I demanded I have it removed, I already started feeling better the very next morning. So many women also commented on my post sharing their own awful experiences, and if you search you will find info about all the lawsuits filed by women that went through these experiences as well.
  • @ymese
    Please consider doing a podcast solely focused on the perimenopausal stage of a woman’s lifecycle. It is so difficult to find useful, evidence based information on this topic. Every woman I know in my age group is struggling through it silently. Thank you! (Ps - Really love and appreciate your podcast and have learned so much!)
  • @elenkp5253
    I m suffering with PCOs and endometriosis. I d really appreciate an episode going on detail about endometriosis and supplements or tests we need to do and take, and how we can treat these conditions as naturally as possible! I enjoy listening to you for the past couple years!! Thank you
  • A little side note about copper IUDs. I also thought as a person very sensitive to hormones, a copper IUD would be a perfect solution for me. I had it in for 7 years before I got pregnant with it. After that child was born, my post baby body was difficult to get back to say the least. We did some testing and my thyroid was under performing. I did a reinsert of an IUD after a 2nd child and I had some SERIOUS neurological symptoms. I was seeing specialists consistently with no answers. As soon as I took that IUD out, everything resolved itself. I’m pretty convinced the copper IUD caused my thyroid performance and my neurological symptoms after the 2nd insertion. Just some important things to think about before recommending this birth control method for women. Barrier method of some form is the best for our health
  • This podcast has helped me more than all my doctors ever had in my 33 years of existence.
  • @misscarlyle
    Andrew, you're the man. Bringing women's health issues to the forefront is so important. I have had issues for years and am dismissed, I recently asked for a hormone test as my migraines are happening with hormone fluctuations. My doctor said it's "pointless" as all hormones fluctuate. Love being dismissed. I have kept a journal for 6+ years with dates/symptoms and he didn't even look at it.
  • @PlayshotKalo
    Can we just appreciate Huberman for his health curiosities and presenting that accumulation of knowledge he has to us? Thank you Huberman for helping us try to be our best selves. I wish you a long, healthy, happy, fulfilled life.
  • @jesshatchette
    I want a whole video with her for perimenopause and menopause! This affects women as early as our late 20s and early 30s. We really need this information.