How to Prevent Almost ALL Disease - The Medlife Crisis Podcast #1

Thanks for having me round your garage, Dr Crisis! If we cure ageing, we can look forward to decades of extra healthy life to enjoy nearly-two-hour YouTube interviews.

Rohin's Facial Foliage Deserves a channel of it's own

Very informative and pleasurable interview. Thank you from a 76 year-old who lives a life of gratitude, pays attention to diet, exercise, (including taking the stairs from and to my 8th floor apartment), and who I let into my emotional space. I remain pain and meds-free, and feel this is the best time in my life so far.

Time-Stamp Breakdown of Facial Hair: 0:00 - Full Frontal Foliage 1:15 - Subtle Stubble 4:21 - Marvellous Moustache

Timestamps / Chapters 0:00 Intro 5:37 Why you got into the anti-ageing field? 7:15 Ageing as a cause of death 9:18 What is ageing? 13:32 Hallmarks of Ageing - Senescent Cells 17:25 How do we target senescent cells? 20:10 What are telomeres? 22:40 How do we stop telomeres shortening? 26:00 Evolution optimised for reproduction, not ageing well - BOFFFs 33:54 Autophagy - cellular recycling 42:00 Testing of rapamycin - Effective Dose 45:35 Why don't we have human data on rapamycin? 46:24 Metformin - TAME trial monetary issues 49:04 What is Metformin? 52:50 How does Metformin work as an anti-ageing drug? 54:03 What therapies excite you at the moment? 58:39 Thoughts on Calorie restriction 1:04:53 Rhesus Monkey Diet Trials 1:08:14 Potential Therapies - theoretical mechanistic science 1:12:46 Amyloid Studies 1:17:20 Should we stop ageing? 1:31:29 Where do you see the anti-ageing field being in 2050? 1:43:03 Outro

Was driving. Now listening while parked against a tree.

Kids who watched Phineas and Ferb know exactly what an aglet was.

The Nietzche mustache is making my day

Growing up I had a high opinion on all sorts of medical interventions. While studying chemistry and biochemistry, I got more and more disillusionised to what medicine is really capable of. Learning how finely tuned our bodies homeostasis works and following the medical news where common practices and medications are retracted on a regular basis because they don´t work after all, you really get more pessimistic. Rohin has a very realistic view on that, which I like.

Mustache is FABULOUS. If I were to select my family doctor based on a photo of the doctor, a person with this kind of mustache would get me as a client 100% of the time

Describing an opossum as "a sort of cat-sized rat," is temarkably accurate 😂. Thanks for another fascinating and enlightening video!

In 2014, as a mature-aged student, I got my degree in Molecular Biology and Biomedical Science - largely due to people like Aubrey de Grey, who was only briefly mentioned at the end of the video. For a long time these ideas were seen as "fringe science" or not as scientific at all, so I think it might have been nice to pay some respects to those who fearlessly pioneered the whole concept of increasing life-span and health-span via biotechnology and serious research into both ageing mechanisms and potential interventions based on what we learn about those mechanisms. It's only been in the last few decades - literally as I grew from a teenager to an adult (now 43) that those pioneers forced the scientific community to take this field seriously. It's a major achievement by Nir Barzilai to have convinced the FDA to allow an interventional study that treats ageing itself, as they previously refused to classify ageing as a target pathology. Hopefully people interested in this stuff, who can now see serious discussions and papers on it in virtually any health-related sphere, realise the paradigm shift they are looking at and will undoubtedly benefit from.

It's always exciting to see a video from Rohin Let alone a video about a topic that's saturated with medbros and pedlers of sudoscientific nonsense Let alone a video that's the length of an extendened documentary All the best things rolled into one That was a very very interesting watch/listen. I'm vaguely familiar with Andrew's stuff and hearing more from him is always good (I should really subscribe) The next 30 years look to be full of very interesting things in terms of medical science from the studies being done just now, to ones that could be done in the near future I like to think that I'll get to live to at least 120 years old but I'm very clued into how short one's natural life can be considering I live in Glasgow (a very depressing shout-out but it's one that's present in the minds of everyone I know haha) Very exciting and interesting Rohin should do more podcasts (if he can get the time)!

the algorithm has been hiding this from me since its release, i think youtube hates podcasts now. great work as always! you never fail to cover interesting topics and bring up insightful questions, leaving me to rethink my career choice in chemistry. fascinating stuff.

Fascinating! An entertaining and informative overview of how anti-ageing keeps turning into "oops, it's cancer again!"

I've had a Nebula subscription for over a year but I still watch 90% of the creators' videos on YouTube because there's no comment functionality on Nebula.

Focusing on the ageing process instead of what ageing risks causing reminds me of the saying "An ounce of prevention is worth a pound of cure"

Portraits of the two greatest doctors of all time in the background.

Very interesting to me, as the caregiver for my 97 yo mother. Bedbound and in hospice due to dementia, but very strong physically with better skin and vitals than most 50 yo. Her nurse said she did not know what would be the cause of death. Mom is forgetting how to swallow and therefore harder to feed, so that will probably be the cause , in my opinion.

Hyped for some well evidenced, grounded conversation about longevity! I'd like to make it to the triple digits, and I'd like to hang out with my parents for a good portion of that time as well. Immortality would be nice, but another decade where I can spend quality time with family would be nice too :)