Conversation With A Rare Dinitrophenol Accident Survivor (DNP For Weight Loss)

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Published 2021-02-26
Patient in this case is ‪@East-Bound‬ (check out his YouTube Channel!)
‪@chubbyemu‬ video of this case:    • A Man Swallowed Lab Chemicals To "Los...  
Christopher's recount of his case:    • How My Weight Loss Journey Almost Cos...  

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Timestamps:
0:00 - Introduction
0:30 - Can you tell me about yourself?
1:21 - How did you get into lifting weights?
3:14 - Bernard talking about his high school experience
4:12 - What was your relationship like with the gym?
5:48 - How did things change in Christopher's life at the end of high school?
8:17 - Other people's perception of weight
9:24 - Christopher describing long time girlfriend cheating on him
10:32 - People judging others based on weight
14:45 - How did you get back in to fitness during college?
17:54 - Weight loss plateau
20:54 - Weight loss supplements
24:46 - Transition from supplements to harder weight loss chemicals
31:04 - What is clenbuterol like?
33:40 - How did you come across DNP?
35:41 - What is being on DNP like?
40:00 - How long did you take DNP for?
44:58 - What do you remember from day of accident?
50:19 - Tales from the emergency room, September 3 2015
51:10 - Waking up in the ICU
55:25 - How did the accident change your relationship with the gym?
57:54 - What would you tell someone thinking of taking DNP today?

2,4-Dinitrophenol (DNP) is a chemical that is not approved for weight loss. It is a classic case of efficacy, but without safety in the setting of weight loss. This setting of weight loss can be prone to chemical misuse, further exacerbating understanding in human systems. Christopher is one of 2 - 3 cases documented in literature to have survived an accident with DNP for weight loss. As of 2021, one organization has permission from the US FDA to investigate DNP in some neurodegenerative disorders. These are rare diseases with limited standards of care, therefore extenuating circumstances to find anything that could potentially improve patient outcomes.

References:

Role of dantrolene in dinitrophenol (DNP) : A continuing question? Am J Emerg Med. 2019 Jun;37(6):1216.e1-1216.e2. pubmed.ncbi.nlm.nih.gov/30948257/

2,4-dinitrophenol (DNP): a weight loss agent with significant acute toxicity . J Med Toxicol. 2011 Sep;7(3):205-12. pubmed.ncbi.nlm.nih.gov/21739343/

Ambient temperature and mortality from unintentional . JAMA. 1998 Jun 10;279(22):1795-800. pubmed.ncbi.nlm.nih.gov/9628710/

Beware the yellow slimming pill: fatal 2,4-dinitrophenol. BMJ Case Rep. 2016 Apr 4;2016. pubmed.ncbi.nlm.nih.gov/27045052/

Dantrolene is not the answer to 2,4-dinitrophenol poisoning: more heated debate. BMJ Case Rep. 2018 Dec 19;11(1):e225323. pubmed.ncbi.nlm.nih.gov/30573533/

The effect of 2,4-dinitrophenol on adipose-tissue metabolism. Biochem J. 1969 Feb;111(4):431-44. pubmed.ncbi.nlm.nih.gov/4388239/

The mechanism of uncoupling of oxidative phosphorylation by 2,4-dinitrophenol. J Biol Chem. 1967 Oct 25;242(20):4577-83. pubmed.ncbi.nlm.nih.gov/4964808/

MECHANISMS OF DINITROPHENOL TOXICITY. Simon E.W. Biological Reviews. Vol 28. (4). Nov 1953.

Identification and Importance of Brown Adipose Tissue in Adult Humans. www.nejm.org/doi/full/10.1056/NEJMoa0810780

Mitochondrial uncoupling as a target for drug development for the treatment of obesity. Obes Rev. 2001 Nov;2(4):255-65. pubmed.ncbi.nlm.nih.gov/12119996/

LC-MS-MS analysis of 2,4-dinitrophenol and its phase I and II metabolites. J Ana Toxicol. Jan-Feb 2007;31(1):55-61. pubmed.ncbi.nlm.nih.gov/17389084/

Uncouplers of oxidative phosphorylation. Environ Health Perspect. 1990 Jul;87:213-8. pubmed.ncbi.nlm.nih.gov/2176586/

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All Comments (21)
  • @djp1234
    He'd rather try to survive this overdose at home than get hit with the ambulance bill. Fuck our healthcare system.
  • @snarr
    I really appreciate this interview. It brings a whole new level of relatability/empathy to hear from the patient themselves.
  • The story of his father's death and the way he blamed himself is heartbreaking. Great video.
  • @emmonstrex65
    First- this interview works on many levels, because you were as interested in his story as your viewers. Mainstream interviewers love to hear themselves talk- which negates what/who the story is about. When that happens, the viewer gets very frustrated. Second- this is REAL. As someone who has always had issue with weight, this is supremely relevant on a personal level. Third- this story is about the male experience. It's always about women- as our worth, culturely, seems to be closely tied to our appearance but men also have this same issue, just not discussed. My darling son needs to watch his weight- his self worth and his career (US Navy) are tied to his weight and appearance. I will make sure he watches this when he gets back (on deployment now). Lastly- this interview gives so much pertinent information! Sorry for the long post- it's just that this interview moved me so very much.
  • @Q_z_
    I love the emotional/personal nuance that this adds to the medical side of cases. It goes to show a symptomatic diagnosis can be achieved with science, but finding the root cause goes deep past the scientific and it's imperative to look at the personal and emotional aspects.
  • @reu2002
    I’m an ICU survivor, also from an overdose. It’s an incredibly traumatic and destabilising experience that takes years and years to unpack. I also experienced learning when I woke up that the clinicians had told my family I might not make it. The guilt of that is immense. Thank you for talking so openly about what happened to you.
  • @Jacqueline888
    the way he talks about his own actions and thought processes shows such an amazing level of self awareness and accountability. remarkable stuff.
  • @genevamarie7502
    So important to hear stories about men/masculine folks struggling with body issues. I think the body positive movement often turns a blind eye to men. I love that we can start to accept women/ feminine folks at all sizes, but we need to recognize that men/ masculine folks need acceptance and love at any size too.
  • A friend of mine had a aneurism and almost died at 29 because he took hydroxycut but was abusing supplements and taking too many different ones. He was in the ICU for weeks but by a miracle he survived.
  • I guess that's what happens when you try to mess with the powerhouse of the cell...
  • I'm only 15 minutes in at this stage but as a female it's so different hearing men talk about the effects of body negativity and negative comments I'm so use to hearing women talk about it and I'm use to my own inner voice but its bringing me to tears hearing these 2 men talk about it and not only that but so openly and almost for lack of a better word in such an emotionless way Dont know why its setting my emotions off so much
  • @minkz4097
    I had never heard men talking about eating disorders and struggles with self image, only women.. yet his experiences and the whole mindset he describes is SO similar to what I went through when I had anorexia as a teen.
  • @4nn13h7
    I went through a similar “transformation“ as a 25-year-old. I cannot imagine going through it as a teen. To feel OK about your body for the first time is one hell of a drug, and there is lots of positive support four athletic pursuits and other activities people perceive as attractive or healthy. But there is little support when those activities become self destructive and toxic.
  • @whirleybyrd9319
    He’s such a brave and handsome guy. He doesn’t need to change a thing about himself.
  • @kiraqify
    Man it really peeves me off that people think they can tease someone or treat them poorly because they're overweight.
  • @reyd286
    "What borders on an eating disorder" It really does sound like a genuine eating disorder. They're not recognized as much in men but I feel there's not much difference between intentionally, painfully working off all your calories for the day and not eating them in the first place. of course that's different if you're an athlete and you happen to work off more than you eat.... but I'm also certain there are athletes with disordered eating habits. If female gymnasts and dancers are anorexic for trying to fit the image their trainer wants, then male weightlifters and football players can be disordered for overworking themselves to the point of pain, torment, injury just to achieve their fitness goals
  • @mimisezlol
    55:40 hold on, why isn't anyone talking about the fact that Dr. Bernard was hit by a car twice?
  • @gioworno
    Dayum, 1 hour * Grabs popcorn *
  • @beverlyhigh620
    Thank you for presenting this Dr. Bernard and Christopher. My daughter talks about weight loss supplements and most/all are shams. Walk more, eat less, eat better. I've shown her this video, I hoping she listens to the message