Top 4 Inherited Mental Health Disorders: What You Need to Know

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Published 2024-05-15
Psychiatrist Dr. Tracey Marks explains the top 4 mental health conditions with the highest heritability (greatest genetic influence). She discusses what heritability means, the role of environmental triggers, and how knowing your family history can help you prioritize your mental health.

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References from the video:
McIntyre, Roger S et al. ā€œBipolar disorders.ā€ Lancet (London, England) vol. 396,10265 (2020): 1841-1856. doi:10.1016/S0140-6736(20)31544-0

Brancati GE, Nunes A, Scott K, O'Donovan C, Cervantes P, Grof P, Alda M. Differential characteristics of bipolar I and II disorders: a retrospective, cross-sectional evaluation of clinical features, illness course, and response to treatment. Int J Bipolar Disord. 2023 Jul 14;11(1):25. doi: 10.1186/s40345-023-00304-9. PMID: 37452256; PMCID: PMC10349025.

Scaini G, Valvassori SS, Diaz AP, Lima CN, Benevenuto D, Fries GR, Quevedo J. Neurobiology of bipolar disorders: a review of genetic components, signaling pathways, biochemical changes, and neuroimaging findings. Braz J Psychiatry. 2020 Sep-Oct;42(5):536-551. doi: 10.1590/1516-4446-2019-0732. PMID: 32267339; PMCID: PMC7524405.

Nowrouzi B, McIntyre RS, MacQueen G, Kennedy SH, Kennedy JL, Ravindran A, Yatham L, De Luca V. Admixture analysis of age at onset in first episode bipolar disorder. J Affect Disord. 2016 Sep 1;201:88-94. doi: 10.1016/j.jad.2016.04.006. Epub 2016 Apr 27. PMID: 27182964.

Bolton S, Warner J, Harriss E, Geddes J, Saunders KEA. Bipolar disorder: Trimodal age-at-onset distribution. Bipolar Disord. 2021 Jun;23(4):341-356. doi: 10.1111/bdi.13016. Epub 2020 Nov 3. PMID: 33030292; PMCID: PMC8359178.


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All Comments (21)
  • @susanhunter9196
    I think an ADHD & ASD assessment should be done on every child before they start school. Knowing that your brain works in a different way could be a life changing event for a lot of kids. Maybe, it would keep some kids out of jail and off drugs. I was undiagnosed till 59 and, my life has been a roller-coaster ride straight through hell.
  • SO much of this is also dependent on how honest and proactive families / parents are in even investigating mental illness. If no one in your family even speaks of mental illness, getting your own help can be extremely difficult
  • I have autism, and ADHD and possibly OCD and C-PTSD. My main diagnosis is Avoidant Personality disorder. These wonderful problems were discovered when I was 61 years old. I'm unable to have adult personal relationships. This leaves me alone and depressed. I turn 70 this year. I Don't know if anyone understands loneliness like I do. I don't know if it's genetic or not, but no one's in danger of inheriting any thing from me. My disorders prevented that.
  • @brittm1960
    Thank you. I am Asian and mental health isnt spoken about it... until me. I was diagnosed with bipolar 2 in Jan 2023 at the age of 35. I later learned my mother was undiagnosed & unmedicated bipolar, and my grandpa had it. I am happy that i am not having children. I do not want to pass this on to a child.
  • @tamekiab1499
    My family (Great Aunt, cousin, sister) on my mother's side has schizophrenia and I'm diagnosed with MDD and anxiety. My children both have autism, with my daughter also having ADHD. This is so eye opening šŸ˜¢
  • @Lojo7820
    Just diagnosed with ADHD in my 40ā€™s. Watching my son like a hawk.
  • @whitneyc.3257
    Summary: Severe Mental Illnesses (Bipolar disorder and Schizophrenia), Autism and ADHD
  • Never had kids. As I was growing up I knew I shdnt re-produce. Probably the only correct decision Iā€™ve made in my 63yrs walking this planet
  • @LDiamondz
    When I was severely depressed, I went to a psychiatrist for the first time. She diagnosed me with bi polar, and put me on 3 different medications. I had extreme reactions to them. Because I wasn't bi polar. I had Major Depression. (Which another doctor diagnosed after several visits.) First doctor was too quick making a dx after one visit, probably because my sister had it.) Smh.
  • @JustChaela1
    It was first brought to my attention that I might have ADHD at my sonā€™s assessment and I was not even speaking. I was floored. That was about 10 years ago. I just started treatment this year.
  • @gbriank1
    We need more discussion of Panic Disorder and Generalized Anxiety.
  • @HLJlovejoy
    This channel helps me to be patient, empathetic and supportive especially when Iā€™m at the end of my caretaker rope. I come here to get perspective & more understanding. ā¤
  • Very, very good video. As a parent of a child with ADHD, Iā€™ve been thrust into a totally new world of which knowledge is power. Now knowing what I know, I realize my ex-husband had all the symptoms, but didnā€™t know it at the time. Grateful for you Dr. Marks for keeping us informed!
  • @yogiperogy
    I thought it weird that I was in my late 50s before my diagnosis was changed from major depressive disorder to bipolar disorder, fortunately Type 2. This explains what was going on with me. I now take two antidepressants and a mood stabilizer. I was depressed as a child but my motherā€™s shame was such that I had to reach the age of majority, get my own health card and seek treatment. She was unmoved by a suicide attempt. Fortunately for people suffering today the mental health stigma of yesteryear has largely subsided.
  • @jryland6
    Dr Marks you have made more since in the 1st 5 mins of this video than anyone Iā€™ve ever spoken with. Thank you. ā¤
  • I wish Dr Tracey could assess me. I have a slew of disorders: Bipolar 1, CPTSD, anxiety, ADHD, & Substance Use Disorder. I self medicated with illicit drugs for 20yrs before a psychiatrist actually listened to me after 6 voluntary & 1 involuntary commitment. "We treat mental health patients here, not drug addicts," at 5 different hospitals. Mental health & substance use disorder are connected apparently for many Drs. I had to go into the field of behavioral health to treat my damn self.
  • @caesarq7513
    I had also heard that after about 3 episodes of someoneā€™s predisposition to bipolar being activated the disorder becomes self perpetuating and will continue to cycle on its own without any additional triggers unless treated.
  • @djkenny1202
    My mom has heavy ADD. Was traumatized as a child. I feel I carry these traits. I had terrible anxiety over a decision all week, now Iā€™m depleted. Can barely get anything done. My son has Autism and ADHD. I cannot sleep long, I awake at 2am. He gets all the supports, while acts out a lot, discipline issues, heā€™s doing very well.