Von Willebrand Disease (VWD) | The Most COMPREHENSIVE Explanation!
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Publicado 2020-06-13
Von Willebrand disease (vWD) is the most common inherited bleeding disorder worldwide.
Primary hemostasis involves forming a platelet plug (thrombocytes) whereas secondary hemostasis involves making a fibrin thrombus (coagulation factors).
Ionized calcium helps blood coagulate.
We test for primary hemostasis via platelet count, bleeding time, and platelet aggregometry.
We test secondary Hemostasis via prothrombin time (PT), activated partial thromboplastin time (aPTT), and the old coagulation time (or clotting time, or thrombin time).
Von Willebrand Dusease (vWD) affects primary as well as secondary Hemostasis.
Hemolytic Uremic Syndrome (HUS), atypical Hemolytic Uremic Syndrome (aHUS), and Thrombotic Thrombocytopenic Syndrome (TTP).
Atypical hemolytic uremic syndrome (aHUS) is similar to thrombotic thrombocytopenic Purpura (TTP).
Typical Hemolytic Uremic Syndrome (HUS) is a triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure.
Thrombotic thrombocytopenic purpura (TTP) is a pentad of microangiopathic hemolytic anemia, thrombocytopenia, acute renal failure, fever, and neurological abnormalities.
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Bernard-Soulier Syndrome (BSS) is an autosomal recessive (AR) disorder characterized by a defective GP1b platelet receptor leading to a problematic platelet adhesion process (primary hemostasis).
Glanzmann Thrombasthenia (GT) is an autosomal recessive defect in the GPIIb/IIIa (GP2b/3a) receptor on the platelet which leads to defective platelet aggregation.
Ristocetin Cofactor Assay (RIPA) is usually abnormal in cases of Bernard-Soulier Syndrome (BSS).
Bleeding time is prolonged, platelets are big in size, but few in number (Macrothrombocytopenia).
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Platelet count is one of the lab tests used by a doctor or a hematologist to assess whether your platelet number is normal, low (thrombocytopenia) or high (thrombocytosis).
Bleeding 🩸 time (BT) is another test for platelet function.
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Todos los comentarios (21)
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I am not a medical student, but I do have type 3 vWD. I was able to understand some of this video and even learned some new things. Thanks so much :)
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As students, many teachers and educators will pass through our lives without remembrance. Yet, a special few will leave a lasting impression. Thank you for being one of the special educators who will live on forever in the minds and hearts of the students whose lives you have touched ❤
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"Oooh I made the soup" "Shut up you didn't "😂 I love it
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The best video on Von Willebrand disease. The best channel on hematology. From Nigeria 🇳🇬❤️
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Peter schmeichel, manchester united, fan. My favourite yt channel just got a whole lot better ! Amazing videos, great content. Your humor is absolutely top-notch !
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I want to tap on every topic of my notes and listen its summary in your voice hahahahaha awesome video btw!!!
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Thank you so much for making us understand in the most simplest way💓
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Watching and learning from beautiful Greece!! :hand-pink-waving:
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This is really interesting and couldn't resist my laughter after listening your change in dialects....love you mahnn❤️
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@12.00 the Soup analogy was EPIC! Love your videos and learning a lot! THANK YOU !
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My friend told me that she has VWD and I really want to somehow support her and thanks for your videos I can know more. Thank you
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I'm finally understanding hematology! You are brilliant ,thank you so much❤️
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Thank you so much for this video. I have type 1 vWD and wanted to learn more about my disorder but I just didn't know where to find it. You've made me feel seen and I thank you for that.
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So cool, funny, and understandable man! Love it!
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I love you and your videos so much!
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Forever in my heart! Thank you! ❤️
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You explanation it’s supercalifraglisticexpialidocious .🙏🏼thank you
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🌸Love the drawing .. really helpful.. Thank you so much medicosis for all your efforts🌸 .. 💫brilliant 💫
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I only found your videos last week and I love them. Have to say though that you labeled Northern Ireland as Scotland.
