300-Special episode: Peter on exercise, fasting, nutrition, stem cells, geroprotective drugs, & more
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Published 2024-05-06
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In this special edition celebrating 300 episodes of The Drive, Peter discusses a variety of popular topics and health interventions and classifies them based on their level of evidence and relevance using the following categories: proven, promising, fuzzy, noise, and nonsense. Peter first delves into the topic of geroprotective molecules, covering rapamycin, metformin, NAD and its precursors, and resveratrol. Next, he explores the significance of metrics like VO2 max and muscle mass, as well as emerging concepts like blood flow restriction and stem cells. The conversation extends to nutrition, addressing questions surrounding long-term fasting, sugar consumption, sugar substitutes, and the contentious role of red meat in cancer. Peter not only provides his current stance on each topic—most of which have been covered in great detail in the previous 300 episodes—but also reflects on how his opinion may have evolved over the years.
We discuss:
0:00:00 - Intro
0:00:35 - Defining the categories of “proven, promising, fuzzy, noise, and nonsense”
0:07:35 - Rapamycin
0:16:15 - Metformin
0:24:35 - NAD and its precursors
0:34:21 - Resveratrol
0:40:40 - The importance of VO2 max, muscle mass, and muscular strength for lifespan
0:47:02 - Blood flow restriction (BFR) training
0:55:11 - Using stem cells to treat osteoarthritis or injury
1:00:44 - Fasting as a tool for longevity (and why Peter stopped his fasting protocol)
1:12:55 - The energy balance theory
1:19:29 - The idea that sugar is poison
1:31:38 - The idea that sugar substitutes are dangerous
1:39:10 - The debate on red meat and cancer
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About:
The Peter Attia Drive is a deep-dive podcast focusing on maximizing longevity, and all that goes into that from physical to cognitive to emotional health. With over 90 million episodes downloaded, it features topics including exercise, nutritional biochemistry, cardiovascular disease, Alzheimer’s disease, cancer, mental health, and much more.
Peter Attia is the founder of Early Medical, a medical practice that applies the principles of Medicine 3.0 to patients with the goal of lengthening their lifespan and simultaneously improving their healthspan.
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Disclaimer: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions. I take conflicts of interest very seriously. For all of my disclosures and the companies I invest in or advise, please visit my website where I keep an up-to-date and active list of such companies. For a full list of our registered and unregistered trademarks, trade names, and service marks, please review our Terms of Use: peterattiamd.com/terms-of-use/
All Comments (21)
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In this episode, we discuss: 0:00:35 - Defining the categories of “proven, promising, fuzzy, noise, and nonsense” 0:07:35 - Rapamycin 0:16:15 - Metformin 0:24:35 - NAD and its precursors 0:34:21 - Resveratrol 0:40:40 - The importance of VO2 max, muscle mass, and muscular strength for lifespan 0:47:02 - Blood flow restriction (BFR) training 0:55:11 - Using stem cells to treat osteoarthritis or injury 1:00:44 - Fasting as a tool for longevity (and why Peter stopped his fasting protocol) 1:12:55 - The energy balance theory 1:19:29 - The idea that sugar is poison 1:31:38 - The idea that sugar substitutes are dangerous 1:39:10 - The debate on red meat and cancer
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Yes, we like this style of “summary synthesis.” 🙋🏻♀️
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I am addicted to this show, but, it is very healthy addiction.
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"..you see why I get animated, and phosphorylated when people are asking about resveratrol... [taking all these supplements] but not exercising!" I think phosphorylated is my new favorite adjective!
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This podcast is just so helpful it's crazy. More people need to know about this
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This is one of the best episodes! Please do more of this style 🙏
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YES! Please do more of this style! This was a great episode! thank you!
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Appreciate when people are mentally flexible enough to change and base their decision-making off of the evidence, whether or not it agrees with what you thought or hoped to be true. THAT is why I trust this dude.
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I live for these podcasts! Cleaned my entire kitchen and did meal prep while listening to this, and I learn so much each time! I would love to have more of these overview podcasts! Here for as much as I can get.
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I’m appreciative of all 300 episodes. I listen to many health podcasts. You are my favorite and by far, the most trusted. Thank you for your podcast and dedication to the health of humankind. 🥰
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Great conversation- I appreciate how differentiated the questions are answered! That’s Science !
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Thank you, Dr. Attia and Colleagues for bringing this content each year.
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Yes please do more of these!
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Excellent convo gentlemen !! 💯 On On
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You're a legend Petter. Thanks for all the great information
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I like the "rating system", good to use that whenever appropriate and looking forward to the exercise for elderly podcasts.
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Dr. Attia, you can't convince me otherwise, you must have a photographic memory. Mechanical Engineering and MD! At least physical mechanics can be applied to the anatomy. Myself, electrical engineer only because I wasn't smart enough for med school. Now I'm glad I saved my money! Thank you for your continued curiosity and progress above and beyond. I know that personality. I was obsessed with work and continued learning. I was 24/7 with work and fitness. Now the boogie man caught me. So no vision, melanoma of the eye and of course skin cancer, (thanks to blond and blue eyed). I'm fine and planning to be a centurion. Thanks sharing all of your priceless knowledge!!❤
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I love this format. Thanks for all you do Peter!
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Love this concept. Keep'em coming.
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Regarding NMN. I have had a very good experience with it. My recovery has improved, most notably from injury, and I have improved stamina. I was a professional ballet dancer. I lived that life 24/7. I'm fifty-seven and have been working out hard, including weight training and cardio, for most of my adult life, so I know my body. Before I started taking NMN, I was dealing with chronic muscle injuries in my legs, which led to frequent physical therapy. I have not had that trouble since starting NMN two years ago. For example, in the spring, when transitioning from the treadmill to the outdoors, I was always sustaining an injury to my quads, leading to PT, but that's not happening now. I still get the initial injury of what feels like a very localized muscle strain, but instead of worsening, leading to PT, it goes away quickly. There's been no other changes to my routine in life, generally. Also, as I mentioned, I am running longer, and given the importance of VO2 max, I'm even more inclined to stick with it. I take it sublingually.
