Chronic Myeloid Leukemia (CML) | Pathogenesis, Symptoms and Treatment

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Published 2019-02-17

Lesson on Chronic Myeloid Leukemia (CML): Pathogenesis, Symptoms and Treatment. Chronic Myeloid (or Myelogenous) Leukemia (CML) is one type of leukemia, which is a blood cancer with high levels of white blood cells. CML is a leukemia with proliferation of mature neutrophils (PMNs), as evidenced by white blood cells with large nuclei on a blood smear or peripheral blood film. CML often presents asymptomatically, but can progress to having characteristic signs and symptoms of splenomegaly, constitutional symptoms, and lower sternum tenderness.

Pathogenesis of CML is due to the Philadelphia Chromosome, which is a product of translocation of chromosomes 9 and 22, leading to a new fusion gene and protein product. This new protein (BCR-ABL) is an activated tyrosine kinase, which leads to activation of cellular survival and proliferation pathways.

Treatment of CML involves a drug known as imatinib, which has been designed to specifically target the BCR-ABL fusion protein.

I hope you find this video helpful! If you do, please like and subscribe for more lessons like this one :)

Please also check out some of my other hematology videos!

JJ

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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.

Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.

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Thanks for watching! If you found this video helpful, please like and subscribe!
JJ

@janetuwakwe3745 1 year ago

Thank you so much for this video. It just saved me. I'm about writing a hematology exam and CML is one of the major topics. Thank you once again,I'm definitely subscribing to your channel 😃😃

@Greanestbean 6 months ago

Thanks for the video! I think another important point to mention for board exams is differentiating CML from leukemoid reaction using the leukocyte alkaline phosphatase test. The test will be normal to elevated in leukemoid react and decreased in CML.

@allahhuakbar7362 2 years ago

This is one of the best channel

@clinmedunder1036 4 years ago

Thanks for a simple explanation of the pathogenesis of CML! Great video!

@sarojraut330 4 years ago

Beautifully ❤️ and explained.. Thanks

@jenniferakin7203 1 year ago

i was diagnosed with cml around the first of june, 2022. they put me on bosilif 400mg daily. now my white count is normal and my red blood cells are starting to increase too. i go to my cancer dr every three weeks.

@ajjackson9229 2 years ago

I was diagnosed with CML in 2020 and my wbc has always stayed high. Yeah weeks ago I went and had my blood work done and I was at 247,000. I’m on Tasigna.