Squamous Cell Carcinoma & Actinic Keratosis 101...Dermpath Basics & Beyond

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Published 2019-11-04
A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).

More than you ever wanted to know about actinic keratosis (AK) and squamous cell carcinoma (SCC)! This topic seems simple, but in practice it has a lot more nuance than one might expect. I explain the basics and also how I deal with the complicated and tricky cases too. Enjoy!

List of topics discussed (click timestamp to jump to that part of the video):
Basic explanation of AK vs SCC in situ vs SCC invasive: 0:00 to 10:35
Actinic keratosis: 10:35
SCC in situ: 31:37
pigmented SCC in situ: 46:00
HSIL (high grade squamous intraepithelial lesion): 51:50
SCC invasive: 53:00
SCC with cystic change: 1:01:40 & 1:09:35
SCC with perineural invasion: 1:02:40
Lichen simplex chronicus (LSC) vs SCC: 1:06:44
"Atypical endophytic squamous proliferation" (ie SCC vs reactive): 1:12:20
Verruca/wart vs SCC: 1:15:20
SCC with tons of plasma cells: 1:18:35
SCC, acantholytic pattern: 1:20:40
SCC, infiltrative pattern: 1:22:40
SCC, moderately/poorly differentiated & spindle cell SCC: 1:24:25

Other videos you might find helpful:
Normal skin histology 101: kikoxp.com/posts/3660
Basal cell carcinoma 101:    • Basal Cell Carcinoma (BCC) 101 - Derm...  
Keratoacanthoma:    • Keratoacanthoma: cancer or not?  


This video is geared towards medical students, pathology or dermatology residents, or practicing pathologists or dermatologists. Of course, this video is for educational purposes only and is not formal medical advice or consultation.

Presented by Jerad M. Gardner, MD. Please subscribe to my channel to be notified of new pathology teaching videos.

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All Comments (21)
  • on behalf of the brand new PGY-2 dermatology residents- thank you for helping us (for years past and years to come!!)
  • I'm having to review TMAs for my PhD, your video have been immensely helpful! Thank you!
  • @sureshmenon1182
    Excellent Jerad! Thanks so much for your dedication to teaching.
  • @hairyllama5
    Thanks for this video, great practical tips on approaching squamoproliferative lesions in superficial shaves. As a trainee it’s easy to be blasé about these specimens, but with more experience I realise how tricky they can be.
  • @adamronMD
    I’m about half way through and this has been great. The most difficult distinction for me is on Frozen section for excision of SCC in situ especially in these sun exposed areas. Your pace is great. Thank you for putting this together!
  • @user-zp3gk8lb6v
    super rad! Way more info than I need, but as a PA in a rural clinic running a derm clinic, there are loads of little nuggets that help with my day to day for patient management. Thanks
  • @M4790ya
    Great session. Thanks alot DOC
  • @vinvinvino3176
    Thank you Jerad for helping sort through one of the most confusing aspects of dermpath...Even though melanocytic lesions still takes the aces for confusion anyday, I find AK/SCC lesions and their many variants quite challenging too....Thanks a lot!
  • @kamilletuma1191
    Thank you very much for your lesson, Dr. Jerad!!! It helps me a lot during my residency!
  • Thank you Dr. Jerad. Atleast the descriptions mentioned in the book are not just an imagination but already real images from your cases.❤❤
  • I used to fall asleep during histology and pathology sessions in med school. You have a knack of making this subject interesting. Thankyou
  • @tablelegz
    Hey im not a science person so i use this to sleep nice and relaxing works 2 ways i guess